Organic Letters
23 February 2024
Mantidisflavin A: A Riboflavin Derivative Featuring a 6/6/6/5/5 Skeleton from the Egg Cases of the Insect Tenodera sinensis Saussure and Its Anti-Renal Fibrosis Activity
Shi-Gang Peng, Xiao-Ning Liu, Madhu Babu Sura, Yong-Ming Yan, Yong-Xian Cheng
Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, PR China
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China
10.1021/acs.orglett.3c04035
As the folktale goes, "A mantis catches a cicada, unaware of the yellow bird behind", portraying the law of the jungle. Τhe mantis lays eggs protected by an ootheca to ensure continuity. From the egg pod tonic for kidneys that is also beneficial for reproduction, a riboflavin derivative was discovered, providing new insights into insect-derived natural products.
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